Genetic mutation may be responsible for smokers nicotine addiction
By Staff Writer
An individual's genetics may be partly to blame for their vulnerability to developing an addiction to nicotine, according to the results of a recent study.
Based on their findings, German, French and Russian researchers behind the study believe that a brain region known as the habenula may play a role in nicotine addiction.
The researchers identified a specific receptor that nicotine activates in smokers and is encoded by three particular genes. The scientists then examined this receptor and genetic cluster in transgenic mice as well as the egg cells of the African clawed frog.
Of the three genes, the researchers found that a mutation in the one known as alpha5 is present in many smokers. In addition, they believe that this may be linked to a higher likelihood of developing a nicotine addiction in these individuals.
A second gene in the cluster, beta4, is responsible for an increased sensitivity to nicotine. However, the researchers found that when the mutated alpha5 gene is present, a preference for nicotine may override an aversion to the substance.
Young adults who have grown dependent on the nicotine found in cigarettes may want to seek treatment for their addiction from boarding high schools.


